Nearest Neighbor Machine Translation is Meta-Optimizer on Output Projection Layer

Nearest Neighbor Machine Translation ($k$NN-MT) has achieved great success in domain adaptation tasks by integrating pre-trained Neural Machine Translation (NMT) models with domain-specific token-level retrieval. However, the reasons underlying its success have not been thoroughly investigated. In this paper, we comprehensively analyze $k$NN-MT through theoretical and empirical studies. Initially, we provide new insights into the working mechanism of $k$NN-MT as an efficient technique to implicitly execute gradient descent on the output projection layer of NMT, indicating that it is a specific case of model fine-tuning. Subsequently, we conduct multi-domain experiments and word-level analysis to examine the differences in performance between $k$NN-MT and entire-model fine-tuning. Our findings suggest that: (1) Incorporating $k$NN-MT with adapters yields comparable translation performance to fine-tuning on in-domain test sets, while achieving better performance on out-of-domain test sets; (2) Fine-tuning significantly outperforms $k$NN-MT on the recall of in-domain low-frequency words, but this gap could be bridged by optimizing the context representations with additional adapter layers.Comment: Accepted by EMNLP202

What does BERT know about books, movies and music? Probing BERT for Conversational Recommendation

Heavily pre-trained transformer models such as BERT have recently shown to be remarkably powerful at language modelling by achieving impressive results on numerous downstream tasks. It has also been shown that they are able to implicitly store factual knowledge in their parameters after pre-training. Understanding what the pre-training procedure of LMs actually learns is a crucial step for using and improving them for Conversational Recommender Systems (CRS). We first study how much off-the-shelf pre-trained BERT "knows" about recommendation items such as books, movies and music. In order to analyze the knowledge stored in BERT's parameters, we use different probes that require different types of knowledge to solve, namely content-based and collaborative-based. Content-based knowledge is knowledge that requires the model to match the titles of items with their content information, such as textual descriptions and genres. In contrast, collaborative-based knowledge requires the model to match items with similar ones, according to community interactions such as ratings. We resort to BERT's Masked Language Modelling head to probe its knowledge about the genre of items, with cloze style prompts. In addition, we employ BERT's Next Sentence Prediction head and representations' similarity to compare relevant and non-relevant search and recommendation query-document inputs to explore whether BERT can, without any fine-tuning, rank relevant items first. Finally, we study how BERT performs in a conversational recommendation downstream task. Overall, our analyses and experiments show that: (i) BERT has knowledge stored in its parameters about the content of books, movies and music; (ii) it has more content-based knowledge than collaborative-based knowledge; and (iii) fails on conversational recommendation when faced with adversarial data.Comment: Accepted for publication at RecSys'2

A 4-Transistor Monolithic Solution to Highly Linear On-Chip Temperature Sensing in GaN Power Integrated Circuits

We report the monolithic realization of on-chip temperature sensing design using four transistors (4T) in gallium nitride (GaN) technology. The temperature sensor consists of a voltage reference and a logic inverter, both of which are built from enhancement-mode (E-mode) and depletion-mode (D-mode) metal-insulator-semiconductor high-electron-mobility transistors (MIS-HEMTs). The temperature-insensitive voltage reference outputs a very stable voltage as the input of the logic inverter, which exhibits good temperature dependence in its voltage transfer characteristics. As the temperature varies from 25 to 250 °C, the output voltage of the logic inverter changes linearly. By configuring the active-load D-mode transistor as a two-dimensional electron gas (2DEG) resistor in the logic inverter, the temperature sensing solution is improved further, showing stable sensing output, higher sensitivity (31.28 mV/°C), better linearity ( R2 = 0.995) and smaller error (±2.74 °C). This demonstrates a compact monolithic sensor for monitoring the on-chip temperature of GaN power integrated circuits (ICs) for protection and control

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Genetics have nominated many schizophrenia risk genes and identified convergent signals between schizophrenia and neurodevelopmental disorders. However, functional interpretation of the nominated genes in the relevant brain cell types is often lacking. We executed interaction proteomics for six schizophrenia risk genes that have also been implicated in neurodevelopment in human induced cortical neurons. The resulting protein network is enriched for common variant risk of schizophrenia in Europeans and East Asians, is down-regulated in layer 5/6 cortical neurons of individuals affected by schizophrenia, and can complement fine-mapping and eQTL data to prioritize additional genes in GWAS loci. A sub-network centered on HCN1 is enriched for common variant risk and contains proteins (HCN4 and AKAP11) enriched for rare protein-truncating mutations in individuals with schizophrenia and bipolar disorder. Our findings showcase brain cell-type-specific interactomes as an organizing framework to facilitate interpretation of genetic and transcriptomic data in schizophrenia and its related disorders.</p

Comparative genetic architectures of schizophrenia in East Asian and European populations

Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide-significant associations in 19 genetic loci. Common genetic variants that confer risk for schizophrenia have highly similar effects between East Asian and European ancestries (genetic correlation = 0.98 ± 0.03), indicating that the genetic basis of schizophrenia and its biology are broadly shared across populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries identified 208 significant associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping reduced the sets of candidate causal variants in 44 loci. Polygenic risk scores had reduced performance when transferred across ancestries, highlighting the importance of including sufficient samples of major ancestral groups to ensure their generalizability across populations